Fungal infection is one of the major cause of mortality in neutropenic patients. We performed clinical studies to assess the effectiviveness and toxicity of fluconazole for prophylaxis of fungal infection in 20 neutropenic patients, who were
admitted to
Kyung Hee University Hospital from June 1991 to June 1992 and who had a high risk of fungal infection.
@ES The results were as follows.
@EN 1) In 18 case, there was no evidence of fungal infection during the hospital course. One patient had suspicious fungal infection on chest X-ray and clinical finding, and the other case had fungemia confirmed by blood culture. Two patients
died
of
septicemia.
2) Elevation of AST, LAT (15%) G-l trouble (10%) were obserbed as toxicities of fluconazole, but renal dysfuntion, skin rash, or seizure was not obserbed.
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